5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid CAS 4242-18-6 Purity >99.0% (HPLC) Palonosetron Hydrochloride Intermediate

Short Description:

Name: 5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid

Synonyms: 5,6,7,8-Tetrahydro-1-Naphthalenecarboxylic Acid

CAS: 4242-18-6

Purity: >99.0% (HPLC)

Appearance: White or Almost White Crystalline Powder

Intermediate of Palonosetron Hydrochloride CAS 135729-62-3

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid (CAS: 4242-18-6) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid
Synonyms	5,6,7,8-Tetrahydro-1-Naphthalenecarboxylic Acid; 5,6,7,8-Tetrahydro-Naphthalene-1-Carboxylic Acid; 5,6,7,8-Tetrahydro-1-Naphthoic Acid
Stock Status	In Stock, Production Capacity To Tons
CAS Number	4242-18-6
Molecular Formula	C11H12O2
Molecular Weight	176.22
Melting Point	148.0~152.0℃
Boiling Point	336.8±31.0℃
Density	1.184±0.06 g/cm3
Shipping Condition	Ambient Temperatures
COA & MSDS	Available
Brand	Ruifu Chemical

Specifications:

Item	Inspection Standard	Results
Appearance	White or Almost White Crystalline Powder	Complied
Loss on Drying	<1.00%	0.67%
Residue on Ignition	<0.20%	0.03%
Melting Point	148.0~152.0℃	149.9~150.9℃
Purity (HPLC)	>99.0% (HPLC)	99.9%
Assay	98.0~101.0% (Neutralization Titration)	100.9%
1 H NMR Spectrum	Consistent With Structure
Conclusion	This Product by Inspection Accords with the Enterprise Standard
Main Usage	Intermediate of Palonosetron Hydrochloride (CAS: 135729-62-3)

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

Application:

5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid (CAS: 4242-18-6) is an intermediate used for the preparation of the therapeutically useful antiemetic agent Palonosetron Hydrochloride (CAS: 135729-62-3). Palonosetron Hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.